Which medications in the drug class Immunosuppressive Agents are used in the treatment of Diabetic Lumbosacral Plexopathy?

Updated: Jan 04, 2021
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Milton J Klein, DO, MBA  more...
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Immunosuppressive Agents

Immunosuppressive agents such as cyclophosphamide, methylprednisolone, and prednisone may improve recovery.


Cyclophosphamide is a cyclic polypeptide that suppresses some humoral activity. It is chemically related to nitrogen mustards and is activated in the liver to its active metabolite, 4-hydroxycyclophosphamide, which alkylates the target sites in susceptible cells in an all-or-none–type reaction. When used in autoimmune diseases, the mechanism of action is thought to involve immunosuppression due to destruction of immune cells via DNA cross-linking.

Azathioprine (Imuran)

Azathioprine is an imidazolyl derivative of 6-mercaptopurine. It antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. It works primarily on T cells and suppresses hypersensitivities of the cell-mediated type and causes variable alterations in antibody production.

Methylprednisolone (Medrol, Solu-Medrol)

Methylprednisolone is an immunosuppressant that decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability.


Prednisone is an immunosuppressant that can be used for the treatment of autoimmune disorders. It may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear activity. It stabilizes lysosomal membranes and suppresses lymphocyte and antibody production.

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