What is the role of methylprednisolone in the treatment of diabetic lumbosacral plexopathy?

Updated: Jan 04, 2021
  • Author: Divakara Kedlaya, MBBS; Chief Editor: Milton J Klein, DO, MBA  more...
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Answer

Another study, by Dyck et al, suggested that methylprednisolone is effective against diabetic lumbosacral radiculoplexus neuropathy. The double-blind, placebo-controlled study involved 75 patients with the condition, who were randomized to a 12-week regimen of intravenous methylprednisolone or placebo. [41] Although the study’s primary outcome (time to improvement of neuropathy impairment score) was not significantly different between the 2 groups, patients treated with methylprednisolone reported significantly greater symptom improvement, particularly with regard to measures of pain and positive sensory symptoms.


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