Which medications in the drug class Serotonin Norepinephrine Reuptake Inhibitor are used in the treatment of Obsessive-Compulsive Disorder?

Updated: May 17, 2018
  • Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD  more...
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Serotonin Norepinephrine Reuptake Inhibitor

The dual serotonin-norepinephrine reuptake inhibitor antidepressants (SNRIs) venlafaxine (Effexor) and duloxetine (Cymbalta) may also have efficacy in OCD, and they have safety and tolerability profiles comparable to those of the SSRIs. However, neither has yet been FDA approved specifically for the treatment of OCD.

Venlafaxine (Effexor, Effexor XR)

Venlafaxine is a serotonin/norepinephrine reuptake inhibitor. It may treat depression by inhibiting neuronal serotonin and norepinephrine reuptake. In addition, it causes beta-receptor down-regulation. It is used in the treatment of OCD; however, it is not FDA approved for this indication.

Duloxetine (Cymbalta)

Duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake. Its antidepressive action is theorized to be due to serotonergic and noradrenergic potentiation in the CNS.

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