Which medications in the drug class Antipsychotic Agents are used in the treatment of Obsessive-Compulsive Disorder?

Updated: May 17, 2018
  • Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Antipsychotic Agents

Antipsychotics, such as haloperidol, olanzapine, and risperidone, have been used with some success in augmenting SSRIs in patients with OCD, particularly in patients with comorbid Tourette disorder or other tic disorders. These agents are not FDA approved for the treatment of OCD but may be beneficial.

Risperidone (Risperdal, Risperdal Consta, Risperdal M-TAB)

Risperidone is an atypical antipsychotic that has high affinity for both serotonergic and dopaminergic receptors. It also binds to alpha1-adrenergic receptors and, with lower affinity, to H1-histaminergic and alpha2-adrenergic receptors. It is approved to treat patients with bipolar mania, schizophrenia, and irritability associated with autistic disorder.

Olanzapine (Zyprexa, Zyprexa Zydis)

Olanzapine is an atypical antipsychotic agent approved for the treatment of bipolar disorder, schizophrenia, and treatment-resistant depression. It may be helpful in the treatment of OCD; however, it is not FDA approved for this indication.

Lithium (Lithobid)

Lithium is an antipsychotic agent that is indicated for bipolar disorder. It influences the reuptake of serotonin and/or norepinephrine at cell membranes. It has been used in the treatment of OCD; however, it is not FDA approved for this indication.

Haloperidol (Haldol, Haldol Decanoate)

Haloperidol is an antipsychotic agent that exerts its effects through blocking dopamine receptors. It has been used to augment SSRIs in patients with OCD.


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