Which non-FDA-approved interventions have been used to treat obsessive-compulsive disorder (OCD)?

Updated: May 17, 2018
  • Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD  more...
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Other interventions, which have not received an FDA indication for OCD include the following:

  • Addition of an NE reuptake inhibitor, such as desipramine, to an SSRI, or a trial of venlafaxine

  • Addition of a typical or atypical antipsychotic, especially in patients with a history of tics

  • Augmentation with buspirone

  • Addition of inositol

  • Sole or augmented use of selected glutamatergic agents [6, 7]

  • Deep brain stimulation [11, 12] or cingulotomy neurosurgery [13] for severe and intractable cases (see Surgical Care)

Some clinicians feel that individuals with comorbid Tourette disorder or with hoarding as their principal OCD symptom may be more likely to be treatment resistant, although there is significant variation in treatment response, regardless of the particular presenting symptomatology.

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