What is the role of norepinephrine (NE) in the treatment of obsessive-compulsive disorder (OCD)?

Updated: May 17, 2018
  • Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD  more...
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Answer

Several treatment studies suggest a possible role for norepinephrine (NE) in cases of OCD. A subset of patients reportedly shows greater clinical improvement with a combination of 5-HT and NE reuptake inhibition as compared with treatment with SSRIs alone. These have included patients treated with clomipramine and patients whose SSRI treatment was augmented with an NE reuptake inhibitor, such as desipramine. (See Treatment-Resistance Strategies.)


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