Which medications are used in the treatment of obsessive-compulsive disorder (OCD)?

Updated: May 17, 2018
  • Author: William M Greenberg, MD; Chief Editor: David Bienenfeld, MD  more...
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Other interventions, which have not received US Food and Drug Administration (FDA) approval for use in OCD, include the following:

  • Addition of a norepinephrine reuptake inhibitor (eg, desipramine) to an SSRI or a trial of venlafaxine

  • Addition of a typical or atypical antipsychotic (eg, haloperidol, olanzapine, risperidone), especially in patients with a history of tics

  • Augmentation with buspirone

  • Augmentation with ondansetron [5]

  • Addition of inositol

  • Sole or augmented use of selected glutamatergic agents (eg, riluzole, glycine, memantine, ketamine) [6, 7, 8, 9, 10]

  • Deep brain stimulation [11, 12] or cingulotomy neurosurgery [13] for severe and intractable casesb

See Treatment and Medication for more detail.

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