Which medications in the drug class 5-Aminosalicylic Acid Derivatives are used in the treatment of Proctitis and Anusitis?

Updated: Mar 27, 2020
  • Author: David E Stein, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

5-Aminosalicylic Acid Derivatives

These agents are effective in reducing inflammatory reactions. All of the aminosalicylates are useful for treating flares of IBD and for maintaining remission.

Sulfasalazine (Azulfidine, Azulfidine EN)

This agent is considered best for colonic disease, although it is also considered first-line therapy for Crohn disease. It is used for acute disease and for maintenance of remission.

Mesalamine (Apriso, Asacol HD, Delzicol, Pentasa, Rowasa)

Mesalamine is a 5-ASA and acts systemically. It also has activity as a topical anti-inflammatory.

Balsalazide (Colazal, Giazo)

Balsalazide is a prodrug 5-ASA connected to a 4-aminobenzoyl-(beta)-alanine carrier by an azo bond; colonic bacteria break the azo bond, releasing the active 5-ASA. Metabolites of the drug may decrease inflammation by blocking the production of arachidonic acid metabolites in colonic mucosa.

Olsalazine (Dipentum)

This aminosalicylate is useful for active disease and maintenance of remission in ulcerative colitis. Olsalazine is 5-ASA connected to a 5-ASA by an azo bond; colonic bacteria break the azo bond, releasing the active 5-ASA.


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