Which medications in the drug class Immunosuppressants are used in the treatment of Proctitis and Anusitis?

Updated: Mar 27, 2020
  • Author: David E Stein, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Agents in this class neutralize cytokine TNF-alpha and inhibit its binding to the TNF-alpha receptor.

Infliximab (Remicade)

Infliximab, given intravenously, consists of monoclonal antibodies to TNF-alpha. Approved by the FDA for use in IBD, in both Crohn disease and ulcerative colitis. Infliximab is somewhat more effective against CD than UC. The drug appears to promote mucosal healing. Furthermore, it heals perianal and enterocutaneous fistulae and has been shown to reduce signs and symptoms, achieve clinical remission, and eliminate corticosteroid use. Indicated for patients who have experienced inadequate response to conventional therapy.

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