Which medications in the drug class Antispasmodic Agents, Gastrointestinal are used in the treatment of Postcholecystectomy Syndrome?

Updated: Nov 28, 2018
  • Author: Steen W Jensen, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Antispasmodic Agents, Gastrointestinal

Some GI antispasmodic agents inhibit acetylcholine action, and this inhibition in turn inhibits salivation and secretions.

Atropine (Isopto Atropine)

Atropine blocks acetylcholine activity at parasympathetic sites in smooth muscles, the central nervous system, and secretory glands.

Diphenoxylate and atropine (Lomotil)

Diphenoxylate is an antidiarrheal agent chemically related to the narcotic analgesic meperidine. It acts on intestinal muscles to inhibit peristalsis and slow intestinal motility. It prolongs the movement of electrolytes and fluid through the bowel and increases viscosity and loss of fluids and electrolytes. A subtherapeutic dose of anticholinergic atropine sulfate is added to discourage overdosage, in which case diphenoxylate may clinically mimic the effects of codeine.

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