Which medications in the drug class Bile Acid Sequestrants are used in the treatment of Postcholecystectomy Syndrome?

Updated: Nov 28, 2018
  • Author: Steen W Jensen, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

Bile Acid Sequestrants

Patients may benefit from bile acid sequestrants such as cholestyramine and colestipol.

Cholestyramine (Questran, Prevalite)

Cholestyramine may be used to treat diarrhea associated with excess bile acids. It binds bile acids, thus reducing damage to the intestinal mucosa. It also reduces the induction of colonic fluid secretion. It forms a nonabsorbable complex with bile acids in the intestine, which, in turn, inhibits enterohepatic reuptake of intestinal bile salts.

Colestipol (Colestid)

Colestipol forms a soluble complex after binding to bile acid, increasing fecal loss of bile acid–bound low-density lipoprotein cholesterol.


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