Which medications in the drug class Histamine H2 Antagonists are used in the treatment of Postcholecystectomy Syndrome?

Updated: Nov 28, 2018
  • Author: Steen W Jensen, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

Histamine H2 Antagonists

Like antacids, H2-receptor antagonists do not reduce the frequency of reflux but do decrease the amount of acid in the refluxate by inhibiting acid production. All H2-receptor antagonists are equipotent when used in equivalent doses. They are most effective in patients with nonerosive esophagitis. H2-receptor antagonists are considered the drugs of choice for children because pediatric doses are well established and the medications are available in liquid form.

Nizatidine (Axid)

Nizatidine competitively inhibits histamine at the H2 receptor of the gastric parietal cells, resulting in reductions in gastric acid secretion, gastric volume, and hydrogen concentrations.

Cimetidine (Tagamet)

Cimetidine inhibits histamine at the H2 receptors of gastric parietal cells, causing reductions in gastric acid secretion, gastric volume, and hydrogen ion concentrations.

Ranitidine (Zantac)

Ranitidine inhibits histamine stimulation of the H2 receptor in gastric parietal cells, reducing gastric acid secretion, gastric volume, and hydrogen ion concentrations.

Famotidine (Pepcid)


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