Which medications in the drug class Proton Pump Inhibitors are used in the treatment of Postcholecystectomy Syndrome?

Updated: Nov 28, 2018
  • Author: Steen W Jensen, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

Proton Pump Inhibitors

PPIs are indicated in patients who require complete acid suppression (eg, infants with chronic respiratory disease or neurologic disabilities). They should be administered with the first meal of the day. Children with nasogastric or gastrostomy tubes may have granules mixed with an acidic juice or a suspension; tubes must then be flushed to prevent blockage.

Lansoprazole (Prevacid)

Lansoprazole suppresses gastric acid secretion through specific inhibition of the H+/K+ -adenosine triphosphatase (ATPase) enzyme system (ie, proton pump) at the secretory surface of the gastric parietal cell. The drug blocks the final step of acid production, inhibiting basal and stimulated gastric acid secretion and therefore increasing gastric pH. Lansoprazole's effect is dose-related. The drug is easy to administer to children because it is available as a capsule or an oral disintegrating tablet or in granular form for use in an oral suspension.

Omeprazole (Prilosec)

Omeprazole decreases gastric acid secretion by inhibiting the parietal cell H+/K+ -ATPase pump. It is used for both short-term treatment (4-8 weeks) and long-term treatment (up to 12 months) of gastroesophageal reflux disease.

Esomeprazole (Nexium)

Esomeprazole is an (S)-isomer of omeprazole. It inhibits gastric acid secretion by inhibiting the H+/K+ -ATPase enzyme system at the secretory surface of the gastric parietal cells. Esomeprazole is used in severe cases and in patients not responding to H2-antagonist therapy. The drug is administered for up to 4 weeks to treat and relieve the symptoms of active duodenal ulcers; it may be used for up to 8 weeks to treat all grades of erosive esophagitis.

Dexlansoprazole (Dexilant)

Dexlansoprazole suppresses gastric acid secretion by specifically inhibiting the H+/K+ -ATPase enzyme system at the secretory surface of gastric parietal cells.

Rabeprazole sodium (Aciphex)

Rabeprazole sodium suppresses gastric acid secretion by specifically inhibiting the H+/K+ -ATPase enzyme system at the secretory surface of gastric parietal cells.

Pantoprazole (Protonix)

Pantoprazole suppresses gastric acid secretion by specifically inhibiting the H+/K+ -ATPase enzyme system at the secretory surface of gastric parietal cells.


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