When is pharmacologic therapy used to treat postcholecystectomy syndrome (PCS)?

Updated: Jul 24, 2020
  • Author: Steen W Jensen, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Patients with irritable bowel syndrome may benefit from the administration of bulking agents, antispasmodics, or sedatives. The irritable sphincter may respond to high-dose calcium channel blockers or nitrates, but the available evidence is not yet convincing. Cholestyramine has been helpful for patients with diarrhea alone.

Antacids, histamine 2 (H2) blockers, or proton pump inhibitors (PPIs) can occasionally provide relief for patients with gastroesophageal reflux disease (GERD) or gastritis symptoms. One study showed that lovastatin might provide at least some relief in as many as 67% of patients.

For patients with dyspeptic symptoms, Abu Farsakh et al showed that symptoms correlated with gastric bile salt concentration. [6]

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