What is the initial anticoagulation therapy for the treatment of deep venous thrombosis (DVT)?

Updated: Oct 30, 2020
  • Author: Donald Schreiber, MD, CM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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First-line therapy for non-high risk venous thromboembolism (VTE) or pulmonary embolism (PE) consists of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, or edoxaban) over VKAs. [3, 4, 5]  Vitamin K antagonists (VKAs) are also recommended over low-molecular-weight heparin (LMWH), unless VTE is associated with malignancy, in which case LMWH is preferred over VKAs or any direct oral anticoagulants. [3]

Note that it is not recommended that inferior vena cava filters be placed in patients with acute VTE who are on anticoagulant therapy. [3]

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