What is the role of heparin in percutaneous transcatheter treatment for deep venous thrombosis (DVT)?

Updated: Oct 30, 2020
  • Author: Donald Schreiber, MD, CM; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Answer

Most practitioners use concomitant heparinization. Full heparinization was commonly used in conjunction with uPA, whereas the current trend is to administer subtherapeutic heparin with tPA. Low-molecular-weight heparin (LMWH) has not been studied in this setting.

In the coronary literature, enoxaparin improved outcomes (death and myocardial infarction reduced from 12% to 9.9%), but it significantly increased bleeding complications (from 1.4% to 2.1%).


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