Which medications in the drug class Thrombolytics are used in the treatment of Ischemic Stroke?

Updated: May 27, 2020
  • Author: Edward C Jauch, MD, MS, FAHA, FACEP; Chief Editor: Helmi L Lutsep, MD  more...
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Answer

Thrombolytics

Thrombolytic—more accurately, fibrinolytic—agents convert entrapped plasminogen to plasmin and initiate local fibrinolysis by binding to fibrin in a clot.

Alteplase (Activase)

Alteplase is a t-PA used in management of acute myocardial infarction (MI), acute ischemic stroke, and pulmonary embolism. Safety and efficacy with concomitant administration of heparin or aspirin during the first 24 hours after symptom onset have not been investigated.


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