Which genetic factors increase susceptibility to ischemic stroke?

Updated: May 27, 2020
  • Author: Edward C Jauch, MD, MS, FAHA, FACEP; Chief Editor: Helmi L Lutsep, MD  more...
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A number of genes are known to increase susceptibility to ischemic stroke. Mutations to the F2 and F5 genes are relatively common in the general population and increase the risk of thrombosis. Mutations in the following genes also are known to increase the risk of stroke:

  • NOS3: A nitric oxide synthetase gene; involved in vascular relaxation [26]

  • ALOX5AP: Involved in the metabolism of arachidonic acid [27]

  • PRKCH: Involved in major signal transduction systems [28]

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