What are the risks of anticoagulation-related major bleeding in patients with deep venous thrombosis (DVT)?

Updated: Jun 06, 2019
  • Author: Kaushal (Kevin) Patel, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Anticoagulation-related major bleeding is associated with an increased risk of death and thrombotic events, independent of the class of anticoagulant used. Although older agents of anticoagulation and their reversal are well studied, the newer agents lack similar antidotes. With the increasing use of non–vitamin K antagonist oral anticoagulants (NOAC), the number of patients who require reversal of their anticoagulant effects can be expected to rise. The following section describes the reversal agents for both older and new anticoagulants.


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