What is the efficacy of a selective D-dimer testing strategy for the exclusion of deep venous thrombosis (DVT)?

Updated: Jun 06, 2019
  • Author: Kaushal (Kevin) Patel, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

A randomized, multicenter, controlled trial involving 1723 patients found that selective testing of D-dimer levels lowered the proportion of patients who underwent ultrasonography and decreased the percentage of patients who needed D-dimer testing by 21.8%. [107, 108] This suggests that a selective D-dimer testing strategy based on clinical pretest probability (C-PTP), as opposed to testing all patients presenting with symptoms of a first DVT episode, can exclude DVT in more patients without increasing the rate of missed diagnoses.


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