What are the clinical findings in polycystic liver disease (PCLD)?

Updated: Jun 12, 2018
  • Author: Robert E Glasgow, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

Polycystic liver disease (PCLD) rarely arises in childhood. These cysts are observed at the time of puberty and increase in adulthood. They occur as part of a congenital disorder associated with polycystic kidney disease (PKD). Women are more commonly affected, and an increase in cyst size and number is correlated with estrogen level. In PCLD, hepatomegaly may be prominent, and patients occasionally progress to hepatic fibrosis, portal hypertension, and liver failure. Complications (eg, rupture, hemorrhage, and infection) are rare. However, patients do present with abdominal pain as the cysts enlarge.


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