What are the pathophysiology and etiology of neoplastic cysts?

Updated: Jun 12, 2018
  • Author: Robert E Glasgow, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

Liver tumors with central necrosis visualized on imaging studies are often misdiagnosed as liver cysts. True intrahepatic neoplastic cysts are rare. The cause of cystadenomas and cystadenocarcinomas is unknown, but they may represent proliferation of abnormal embryonic analogs of the gallbladder or biliary epithelium. These cystic tumors are lined with biliary-type cuboidal or columnar cells and are surrounded by ovarianlike stroma. Cystadenoma is a premalignant lesion with neoplastic transformation to cystadenocarcinoma confirmed by tubulopapillary architecture and invasion of the basement membrane.

In a retrospective study, Kim et al investigated the value of quantitative color mapping of the liver’s arterial enhancement fraction (AEF) in the detection of hepatocellular carcinoma (HCC). [3] The investigators determined that when the color maps were analyzed in combination with multiphasic computed tomography (CT) scans, the mean sensitivity for HCC detection reached 88.8%, in comparison with 71.7% sensitivity for HCC detection using the multiphasic CT scans alone.


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