Which medications in the drug class Skeletal Muscle Relaxants (Centrally Acting) are used in the treatment of Pressure Injuries (Pressure Ulcers) and Wound Care?

Updated: Jun 11, 2018
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

Skeletal Muscle Relaxants (Centrally Acting)

Centrally acting skeletal muscle relaxants inhibit reflexes at the spinal level.

Baclofen (Lioresal, Gablofen)

Baclofen may induce hyperpolarization of afferent terminals and inhibit both monosynaptic and polysynaptic reflexes at the spinal level.

Diazepam (Valium, Diastat)

Diazepam depresses all levels of the central nervous system (CNS), including the limbic and reticular formations, possibly by increasing the activity of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter. To prevent adverse effects, the dosage should be individualized and increased cautiously.


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