Which medications in the drug class Antibiotics are used in the treatment of Pressure Injuries (Pressure Ulcers) and Wound Care?

Updated: Mar 26, 2020
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
  • Print


Empiric antibiotics should be started immediately. Initial antimicrobial therapy should be broad-based, to cover aerobic gram-positive and gram-negative organisms and anaerobes.

Silver sulfadiazine (Silvadene, SSD, Thermazene)

Silver sulfadiazine has broad-spectrum antibacterial activity and is associated with relatively few complications in these wounds.

The current formulation contains a lipid-soluble carrier, polypropylene glycol, which has certain disadvantages, including pseudoeschar formation. When this antibacterial agent is formulated with poloxamer 188, the silver sulfadiazine can be washed easily from the wound because of its water solubility, making dressing changes considerably more comfortable.

Mafenide (Sulfamylon)

Mafenide is an alternate agent that penetrates eschar more effectively than silver sulfadiazine. Consequently, it is frequently used on infected wounds that do not respond to silver sulfadiazine. Use mafenide with caution because it can induce metabolic acidosis.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!