What is the role of oxidative stress in the etiology of pressure injuries (pressure ulcers)?

Updated: Mar 26, 2020
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
  • Print
Answer

Under normal conditions, the body is able to handle normal oxidative stress. However, with excessive stress comes increased risk for development of pressure injuries and impaired wound healing. A neutrophil-mediated free radical injury results in excessive oxidase activity, which can cause vascular damage and thrombosis, leading to cell death and tissue destruction. [141, 142, 143]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!