What are the histological findings indicative of malignant transformation of pressure injuries (pressure ulcers)?

Updated: Mar 26, 2020
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

Histologically, this malignant transformation is a well-differentiated squamous cell carcinoma [67] ; however, its behavior is very aggressive in pressure injuries, considerably more so than in burns or osteomyelitis. [68, 66] There is a high likelihood of nodal metastasis at the time of diagnosis. Any long-standing, nonhealing wound should alert the examiner to the need for biopsy.


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