What is the role of reperfusion in pressure injuries (pressure ulcers)?

Updated: Mar 26, 2020
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Answer

Reperfusion has been suggested as a cause of additional damage to the ulcerated area, inducing an ulcer to enlarge or become more chronic—as, for example, when a paraplegic or quadriplegic patient is turned from one side to the other in an attempt to combat prolonged pressure on a given side. The exact mechanism of ischemia-reperfusion injury is yet to be fully understood. Continued production of inflammatory mediators and reactive oxygen species during ischemia-reperfusion may contribute to the chronicity of pressure ulcers.


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