What is the pathogenesis of pressure injuries (pressure ulcers)?

Updated: Mar 26, 2020
  • Author: Christian N Kirman, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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In 1873, Sir James Paget described the production of pressure ulcers remarkably well, and his description is still quite accurate today. [18] Many factors contribute to the development of pressure injuries, but pressure leading to ischemia and necrosis is the final common pathway.

In this view, pressure injuries result from constant pressure sufficient to impair local blood flow to soft tissue for an extended period. This external pressure must be greater than the arterial capillary pressure (32 mm Hg) to impair inflow and greater than the venous capillary closing pressure (8-12 mm Hg) to impede the return of flow for an extended time.

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