What are the embryogenic factors in omphalocele and gastroschisis in congenital abdominal hernias?

Updated: Jul 23, 2019
  • Author: Assar A Rather, MBBS, MD, FACS; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
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Answer

The underlying embryogenic factor in omphalocele and gastroschisis is deficient closure of the developing anterior wall at the umbilical stalk. Variations in lateral fold migration can result in both of these defects. [15] In addition, most children with omphalocele and all children with gastroschisis have intestinal malrotation; their extracoelomic location precludes normal attachment of the intestines to the posterior peritoneum.


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