How are symptomatic adjustments managed during plasmapheresis?

Updated: Mar 08, 2021
  • Author: Elliot Stieglitz, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

If signs of hypocalcemia are present, replacement calcium can be administered either intravenously or orally. Additionally, the whole blood–to–citrate ratio can be titrated to minimize hypocalcemic symptoms, which are usually related to the amount of citrate being used as an anticoagulant. [19]

If signs of hypomagnesemia are present, replacement magnesium can be administered intravenously.

If signs of general discomfort are present, the return rate can be adjusted downward.

If signs of hypotension are present, normal saline boluses can be administered.

If signs of a transfusion reaction are present, the product infusion is discontinued, and diphenhydramine and hydrocortisone are given. In cases of anaphylaxis or respiratory distress, epinephrine can be administered as well.


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