What are category IV disorders in which plasmapheresis is demonstrated or suggested to be ineffective or harmful?

Updated: Mar 08, 2021
  • Author: Elliot Stieglitz, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Category IV indications (disorders in which published evidence demonstrates or suggests apheresis to be ineffective or harmful; institutional review board [IRB] approval is desirable if apheresis treatment is undertaken in these circumstances) include the following:

  • HELLP syndrome (ante partum)
  • Hemolytic uremic syndrome (typical diarrhea-associated)
  • Multifocal motor neuropathy
  • Idiopathic polyarteritis nodosa

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