What are the indications for colon resection (colectomy) in patients with hereditary nonpolyposis colorectal cancer (HNPCC)?

Updated: Apr 05, 2021
  • Author: David E Stein, MD, MHCM; Chief Editor: Vikram Kate, FRCS, MS, MBBS, PhD, FACS, FACG, FRCS(Edin), FRCS(Glasg), FIMSA, MAMS, MASCRS, FFST(Ed)  more...
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Answer

Like FAP, hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited colorectal cancer syndrome. [7] Although patients with HNPCC do not develop as large a number of polyps as those with FAP do, they have an 80% lifetime incidence of colorectal cancer. [15] Surgical resection of the entire colon is the only definitive way of preventing colon cancer. Thus, patients with HNPCC may choose to undergo prophylactic total colectomy or proctocolectomy.


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