How are phyllodes tumors (cystosarcoma phyllodes) staged?

Updated: Oct 10, 2018
  • Author: Donald R Lannin, MD; Chief Editor: John Geibel, MD, DSc, MSc, AGAF  more...
  • Print
Answer

The World Health Organization (WHO) divided phyllodes tumors into the following three categories [21] :

  • Benign (grade 1)
  • Borderline (grade 2)
  • Malignant (grade 3)

In a retrospective multicentric cohort study that included 230 patients who underwent breast surgery for grade 1 (benign; n = 144), 2 (borderline; n = 60) or 3 (malignant; n = 26) phyllodes tumor, [22] Adam et al concluded that the surgical margin should be at least 5 mm regardless of tumor grade. On the basis of a finding that moderate-to-severe nuclear stromal pleomorphism identified a grade 1 subgroup with a higher rate of recurrence, they suggested that the WHO classification could be revised by introducing consideration of nuclear stromal pleomorphism.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!