How are phyllodes tumors (cystosarcoma phyllodes) staged?

Updated: Jul 20, 2021
  • Author: Donald R Lannin, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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The World Health Organization (WHO) divided phyllodes tumors into the following three categories [25] :

  • Benign (grade 1)
  • Borderline (grade 2)
  • Malignant (grade 3)

In a retrospective multicentric cohort study that included 230 patients who underwent breast surgery for grade 1 (benign; n = 144), 2 (borderline; n = 60) or 3 (malignant; n = 26) phyllodes tumor, [26] Adam et al concluded that the surgical margin should be at least 5 mm regardless of tumor grade. On the basis of a finding that moderate-to-severe nuclear stromal pleomorphism identified a grade 1 subgroup with a higher rate of recurrence, they suggested that the WHO classification could be revised by introducing consideration of nuclear stromal pleomorphism.

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