What is the role of biopsy in the workup of phyllodes tumor (cystosarcoma phyllodes)?

Updated: Jul 20, 2021
  • Author: Donald R Lannin, MD; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Open excisional breast biopsy for smaller lesions and incisional biopsy for large lesions are the definitive methods for diagnosing phyllodes tumors. Fine-needle aspiration (FNA) for cytologic examination usually is inadequate for the diagnosis of phyllodes tumors. Core biopsy is more reliable, [21, 22]  but sampling errors may still occur, and it may still be difficult to distinguish the lesion from a fibroadenoma.

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