What are possible complications of vasoconstrictive therapy for lower gastrointestinal (GI) bleeding (LGIB)?

Updated: Jul 26, 2019
  • Author: Burt Cagir, MD, FACS; Chief Editor: BS Anand, MD  more...
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During vasopressin infusion, monitor patients for recurrent hemorrhage, myocardial ischemia, arrhythmias, hypertension, and volume overload with hyponatremia. Nitroglycerine paste or drip can be used to overcome cardiac complications. Selective mesenteric infusion induces bowel wall contraction and spasms, which should not be confused with bowel wall ischemia.

Do not administer vasopressin into the systemic circulation intravenously, because this causes coronary vasoconstriction, diminished cardiac output, and tachyphylaxis. Vasopressin infusions are contraindicated in patients with severe coronary artery disease and peripheral artery disease.

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