Which medications in the drug class Histamine H2 Antagonists are used in the treatment of Upper Gastrointestinal Bleeding (UGIB)?

Updated: Aug 12, 2019
  • Author: Bennie Ray Upchurch, III, MD, FACP, AGAF, FACG, FASGE; Chief Editor: BS Anand, MD  more...
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Answer

Histamine H2 Antagonists

Ranitidine (Zantac, Zantac 150 Maximum Strength, Zantac 75)

Ranitidine reduces basal and nocturnal gastric acid secretion by competitive inhibition of binding of histamine to receptors (H2 receptor) on the gastric parietal cells. As of April 1, 2020, ranitidine was withdrawn from the market due to an increasing number of products containing the contaminant known as N-Nitrosodimethylamine (NDMA).

Famotidine (Acid Controller, Act, Dyspep HB)

Famotidine competitively inhibits histamine at H2 receptor of gastric parietal cells, resulting in reduced gastric acid secretion, gastric volume, and hydrogen ion concentrations.


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