Which medications in the drug class Macrolides are used in the treatment of Clostridioides (Clostridium) Difficile Colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Fidaxomicin was approved in 2011 by the FDA for the treatment of C difficile -associated diarrhea in adults. This agent has a narrower antimicrobial spectrum and alters the gut microflora less than do metronidazole and vancomycin.

Fidaxomicin (Dificid)

Fidaxomicin is a macrolide antibiotic indicated for C difficile–associated diarrhea in adults. This agent is bactericidal against C difficile in vitro, inhibiting RNA synthesis by RNA polymerases.

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