Which medications in the drug class Monoclonal Antibodies are used in the treatment of Clostridioides (Clostridium) Difficile Colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Monoclonal Antibodies

Human monoclonal antibodies that bind to C difficile toxins may be considered with standard-of-care antibiotics to prevent recurrent infection.

Bezlotoxumab (Zinplava)

Bezlotoxumab is a human monoclonal antibody that binds to C difficile toxin B, thereby neutralizing its effects. It is administered as a single IV infusion in conjunction with standard-of-care antibiotics to reduce recurrence of C difficile infection (CDI) in adults who are at a high risk for recurrence.

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