Is nitazoxanide an effective treatment for Clostridium difficile (C diff) colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Answer

Nitazoxanide, a medication used to treat parasites, has been shown to be as effective as vancomycin in a clinical trial for the treatment of C difficile.

A review of 10 clinical trials evaluating the treatment of an initial episode of CDI showed that nitazoxanide and teicoplanin did not demonstrate inferiority relative to vancomycin and metronidazole. [75] However, other antimicrobials, including rifampin, and the toxin-binding polymer tolevamer, did show inferiority compared with vancomycin and metronidazole. [75]


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