What are risk factors for recurrence of Clostridium difficile (C diff) infection (CDI)?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Age greater than 65, severe underlying illnesses, and ongoing antibiotic treatments during C difficile therapy are all risk factors for recurrence. Recurrent infection tends to occur in patients who mount a poor host immune response to C difficile. Persistent disruption of the colonic microbial flora also confers an increased risk. Recurrent infection can result from reinfection with the same strain or a different strain of C difficile.

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