What is bezlotoxumab?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Bezlotoxumab is a human monoclonal antibody that binds to C difficile toxin B and neutralizes its effects. It is used with the standard of care antibiotics to reduce recurrence of CDI in adults who are at a high risk of recurrence. Approval was based on the results from the global MODIFY I and MODIFY II studies that showed a single dose of bezlotoxumab is superior to placebo in the prevention of CDI recurrence through 12 weeks (P = 0.0003 for both trials). [60]

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