What are the recommended metronidazole regimens in the treatment of Clostridium difficile (C diff) colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
  • Print
Answer

The Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) recommend a regimen of metronidazole (500 mg PO TID for 10-14 days) as first-line therapy for mild to moderate disease without complications (lower cost and similar efficacy to PO vancomycin in these patients). [5] For patients who are unable to tolerate oral medication, intravenous metronidazole is effective.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!