How effective is fecal microbiota transplantation (FMT) in the treatment of recurrent Clostridium difficile (C diff) colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Answer

Fecal microbiota transplantation (FMT) is a novel therapy that involves the transfer of stool from a healthy donor to a patient with C difficile infection (CDI) in order to reconstitute the normal colonic microbial flora. [62] FMT has been reported to repopulate the colonic flora, with efficacy rates of greater than 90% demonstrated even in cases refractory to antibiotic therapy. [63] Several studies have shown that FMT by colonoscopy or enema is an effective approach for patients with recurrent C difficile colitis, with clinical success rates of up to 95%. [64, 65]


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