How is severe or complicated Clostridium difficile (C diff) colitis treated?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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In patients with suspected severe or complicated CDI, initiate early empirical therapy while the stool tests are pending. [5] Oral vancomycin (125 mg PO QID for 10-14 days) [5] is recommended as first-line therapy in these cases due to faster symptom resolution and fewer treatment failures than when metronidazole is used. Vancomycin is not absorbed and acts directly at the infection site. Symptomatic improvement can be expected within 2-3 days.

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