What are the CDC recommendations regarding antibiotic prescribing in hospitalized patients to reduce Clostridium difficile (C diff) infection (CDI)?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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CDC promotes improving inpatient antibiotic prescribing to reduce drug resistance and increase patient safety

In a 2014 CDC analysis of data regarding antibiotic prescribing in hospitalized patients, Fridkin and colleagues estimated that a 30% reduction in the use of broad-spectrum antibiotics would result in a 26% reduction in CDIs. [52, 53]  In addition, improvement in physician antibiotic prescribing habits from overuse and incorrect use would also help to reduce antibiotic resistance.

The authors recommended the following measures [53] :

  • Promptly initiate antibiotics for a presumed infection, but first obtain any recommended cultures.

  • Document and specify the drug's indication, dose, and expected duration of use in the patient's medical chart.

  • Reassess the patient within 48 hours based on test results and patient examination; adjust the antibiotic regimen (dose, duration) and/or the agent, or end the antibiotic treatment, as needed.

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