What does biopsy of pseudomembranous plaques show in Clostridium difficile (C diff) colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Biopsy of pseudomembranous plaques reveals an inflammatory exudate composed of mucinous debris, fibrin, necrotic epithelial cells and polymorphonuclear cells. The underlying crypts show disruption by mucous and inflammatory debris. The intervening mucosa shows edema but is otherwise unremarkable.

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