What are the symptoms of Clostridium difficile (C diff) colitis?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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C difficile colonization results in a wide spectrum of clinical conditions, including an asymptomatic carrier state; mild, self-limited diarrhea; pseudomembranous colitis; and fulminant colitis. Most patients develop diarrhea during or shortly after starting antibiotics. However, 25-40% of patients may not become symptomatic for as many as 10 weeks after completing antibiotic therapy.

Symptoms often include the following:

  • Mild to moderate watery diarrhea that is rarely bloody

  • Cramping abdominal pain

  • Anorexia

  • Malaise

  • Fever, especially in more severe cases

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