What are the prognostic factors for severe outcomes in hospitalized patients with Clostridium difficile (C diff) infection (CDI) who have IBD?

Updated: Jul 25, 2019
  • Author: Faten N Aberra, MD, MSCE; Chief Editor: BS Anand, MD  more...
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Answer

Patients with IBD are well known to be at an increased risk for CDI. A study identified 3 independent predictors for severe outcomes in hospitalized IBD patients with CDI: (1) serum albumin less than 3 g/dL, (2) hemoglobin level below 9 g/dL, and (3) elevated serum creatinine above 1.5 mg/dL. [39]

In another study, investigators found that CDI is associated with a worse long-term outcome in patients with ulcerative colitis. [40] In the year following treatment for CDI in these patients, an escalation in medical management was noted. In addition, independent predictors for colectomy within 1 year were infection with C difficile and endoscopically proven severe disease. [40]


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