What is the role of genetic factors in the pathogenesis of hepatic encephalopathy (HE)?

Updated: Apr 04, 2019
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Work focused on changes in gene expression in the brain has been conducted. [15] The genes coding for a wide array of transport proteins may be upregulated or downregulated in cirrhosis and ALF. As an example, the gene coding for the peripheral-type benzodiazepine receptor is upregulated in both cirrhosis and ALF. Such alterations in gene expression may ultimately result in impaired neurotransmission.


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