What is the role of xenotransplantation in the treatment of cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Xenotransplantation may come into use during the next decade. To date, all attempts at xenotransplantation in humans have suffered from severe, early humoral or late cellular rejection and have resulted in patient death. Advances in genetic engineering may lead to the development of swine as an organ donor because its livers are more likely to undergo graft acceptance when transplanted into humans. Once this obstacle is overcome, a determination can be made as to whether a swine liver is an effective substitute for a human liver.


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